The tragic death of Rachel Apa, a 24-year-old athlete who collapsed while participating in the New York City Marathon, has brought attention to the serious medical condition of rhabdomyolysis. This condition, which involves severe muscle breakdown, can occur under extreme physical strain and is often exacerbated by external factors such as dehydration and heat.
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Apa, a former hockey player at Bucknell University, set out to run her first marathon on 1 November 2026. Prior to the race, she communicated with her father, Steve Apa, via text message, expressing her excitement about her physical state. Around 11:30 a.m., shortly after passing the 9-mile mark, she informed her father that she was feeling “amazing.” However, by 1:30 p.m., just two miles from the finish line, her messages took a worrying turn as she sent a text simply stating “ow.” Tragically, Rachel collapsed near the 24-mile mark and was subsequently pronounced dead later that evening after being transported to a hospital.
The cause of death was confirmed as rhabdomyolysis. Dr. Sohaib Imtiaz, Chief Medical Officer at People Inc., explained that rhabdomyolysis can arise when intense physical exertion is coupled with certain risk factors. These include dehydration, extreme temperatures, the use of painkillers like ibuprofen, recent viral infections, or even genetic predispositions like sickle cell trait. Although the specific circumstances surrounding Apa’s case remain unclear, the risks associated with such exertion are well-known.

Rhabdomyolysis results from damaged muscle tissues breaking down and releasing harmful substances into the bloodstream. Dr. Imtiaz elaborated on the complications that can arise from this condition, including a dangerous increase in potassium levels, which can disrupt heart rhythms, kidney failure, and significant drops in blood pressure. Furthermore, he noted that heatstroke can occur simultaneously, complicating the situation further.
The phenomenon of exertional rhabdomyolysis is relatively uncommon in fit and young individuals, yet Dr. Imtiaz emphasised that such cases, though rare, can occur during extended periods of physical activity. He explained how prolonged stress on muscles can lead to energy depletion and cell death, which releases myoglobin and potassium into the bloodstream. These substances can trigger severe medical issues without warning.
Interestingly, individuals may outwardly appear healthy prior to an incident of rhabdomyolysis, making recognition of the condition difficult. Dr. Imtiaz pointed out that common symptoms, such as muscle pain and weakness, do not always manifest until significant damage has occurred. Consequently, it is possible to feel well while the condition silently progresses. He highlighted that early symptoms may go unnoticed, as rising potassium levels can suddenly disrupt the heart’s rhythm, potentially leading to collapse.
To mitigate the risks of rhabdomyolysis, Dr. Imtiaz urged athletes to remain vigilant for warning signs indicating more than just typical muscle soreness. Indicators worthy of attention include persistent or worsening muscle pain, swelling, weakness, less urination or dark-coloured urine, and other symptoms such as nausea, vomiting, or confusion. He also stressed the importance of gradual conditioning, particularly during hot weather when the risk is significantly increased.
Proper hydration is essential for runners, but it is crucial to be mindful of not overhydrating with plain water, which could lower sodium levels to dangerous levels, complicating matters further. Dr. Imtiaz emphasised the importance of understanding personal physical limits and recognising early warning signs, stating that immediate medical assistance is necessary and that one should never wait on symptoms to resolve.
Rachel Apa’s untimely passing serves as a sobering reminder of the potential dangers associated with endurance sports. Her family and community are left to mourn, while the tragic incident has sparked a conversation about health and safety practices among athletes preparing for rigorous physical challenges. Awareness of conditions like rhabdomyolysis is essential in fostering safer environments for all participants in endurance events.
