**’Best Medicine’ Returns for Second Season in September 2026**
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Fans of the popular medical comedy, ‘Best Medicine,’ can look forward to the show’s return this September. The second season is set for its premiere on 22 September 2026, following the successful renewal of the series by Fox in March of this year, just two months after its first season debuted.
Based on the beloved British series ‘Doc Martin’, ‘Best Medicine’ features the talented Josh Charles in the lead role as Dr. Martin Best. The character is a prominent Boston surgeon who leaves his fast-paced life behind to take over a small, private practice in the quaint coastal town of Port Wenn, Maine. Yet, Dr. Best faces significant challenges as he deals with a secret fear of blood, complicating his ability to serve the local community.
Throughout the series, viewers have watched Dr. Best struggle to fit into the close-knit environment of Port Wenn, despite having spent many childhood holidays there. Alongside him are a cast of community members who help or hinder his efforts; this includes teacher Louisa Gavin, played by Abigail Spencer, Sheriff Mark Mylow portrayed by Josh Segarra, his Aunt Sarah, and assistant Elaine Denton, represented by Cree. Together, they explore various medical mysteries that haunt their neighbours.
The upcoming season promises to delve deeper into both Dr. Best’s professional and personal life, particularly following the dramatic cliffhangers from the end of season one. In the concluding episode that aired on 7 April, Dr. Best faced a precarious situation when childhood rival Glendon Ross threatened to unveil his secret. This tension will likely carry over into the new episodes, where Dr. Best may find himself defending his actions before a medical board.
Liz Tuccillo, the show’s showrunner, hinted at complications ahead for Dr. Best. “He’s going to have to make some adjustments to his practice, and there may be a new antagonist in town keeping a close eye on him,” she revealed. Additionally, changes are expected for assistant Elaine, who might reassess her responsibilities to enhance her support for Dr. Best.
While the professional realm will be fraught with challenges, Dr. Best’s personal life is set to evolve as well. Initially, there seemed to be chemistry between him and Louisa. However, a twist occurs when Dr. Best overhears her ex-fiancé Mark proposing a platonic co-parenting arrangement, which may leave viewers eager to see how the love triangle unfolds. Tuccillo teased that the narrative would resume five months later, offering insights into Louisa’s decisions during that time.
The core cast will be reprising their roles in season two, including Charles, Spencer, Segarra, and Potts, alongside others. Spencer took to social media to express her enthusiasm for the renewed series, posting, “Breaking News! We are coming back for SEASON TWO! Thank you all for watching! Mutual delight! I j’adore this cast & these characters.”
Additionally, season two will see the inclusion of two recurring characters who have been upgraded to main cast status. Stephen Spinella and Jason Veasey, who play Greg Garrison and George Brady, co-owners of the local restaurant The Salty Breeze, were confirmed as series regulars. Tuccillo shared her excitement regarding their promotion, noting that they bring warmth and humour to every scene.
Best Medicine’s second season will consist of 14 episodes, maintaining its previous time slot with new episodes airing on Tuesday evenings at 8 p.m. ET. The premiere on 22 September will mark a highly anticipated return to screens.
Viewers wishing to join in on the fun can catch new episodes on Fox, with the option to stream them on Hulu and Disney+ the following day. For those looking to catch up, the first season’s 13 episodes are currently accessible on Netflix, Hulu, and Disney+.
As anticipation builds for ‘Best Medicine’s’ second season, viewers can expect a blend of medical drama, comedic escapades, and twists of interpersonal relationships that characterised the inaugural offering.