**Inspirational Journey of Ralph C. Carmona: Running as a Lifeline Through Alzheimer’s**
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In the heart of California, Ralph C. Carmona, a 75-year-old retiree, has found a lifeline in running, a passion ignited after witnessing his son cross the finish line at the Boston Marathon in 2014. This inspiring journey took an unexpected turn when Carmona was diagnosed with mild cognitive impairment due to Alzheimer’s disease the following year, but he has since turned adversity into opportunity through his commitment to fitness.

Carmona’s path to competitive running was sparked by his son’s success, but his journey became more than just a personal challenge. Following the race, Carmona’s wife, Vana, noticed changes in his memory and behaviour, prompting her to encourage him to seek medical attention. The diagnosis of Alzheimer’s in 2015 left him grappling with feelings of anger and denial, but he quickly learned to channel those emotions into a determined defiance against the disease.
Reflecting on the past decade, Carmona has actively participated in clinical trials aimed at advancing scientific research on Alzheimer’s. Through these trials, he has learned that maintaining an active lifestyle is crucial for healthy ageing. He emphasised the importance of critical thinking, a balanced Mediterranean diet, and regular physical activity which includes running, walking, and swimming, in combatting the effects of Alzheimer’s.
Carmona’s interest in running dates back to the late 1970s when many of his peers, particularly Baby Boomers, were embracing the exercise trend. Despite his early enthusiasm, a series of injuries led him to abandon the sport. However, the sight of his son’s achievement rekindled his passion. “I expressed a desire to run again,” he recalled. With encouragement from Alejandro and Vana, he laced up his running shoes and took the plunge.
His return to running proved transformative. In less than a year after his recommitment to the sport, Carmona completed his first 10K and later tackled a marathon in 2019. More remarkably, he continued to push his boundaries, completing another marathon in 2023. Looking ahead, he aims to participate in the 2025 Boston Marathon, making him the only qualified runner living with Alzheimer’s to compete.
Carmona shares that running has significantly contributed to his mental health, elevating his outlook on life. He views marathons, once deemed insurmountable, as opportunities that demand both mental and physical prowess. The preparation for a race involves meticulous planning, from pacing and hydration to nutrition and endurance—a challenge that he relishes.
Even after crossing the finish line of his most recent marathon, Carmona required assistance, but he celebrated his achievement as he placed first in his age category. “I easily beat the qualifying time for the Boston Marathon next year,” he proudly noted, highlighting his determination and resilience.
In addition to running, Carmona maintains a well-rounded fitness regime that includes swimming a mile on rest days and enjoying daily walks with his dog. His life is rich with other activities as well, including travel and gardening with Vana, all contributing to a balanced lifestyle.
Ten years after his Alzheimer’s diagnosis, Carmona reports that his symptoms remain largely manageable. His neurologist affectionately refers to him as a “rock star,” and medical evaluations indicate he is in the top percentile in physical health—an essential aspect in maintaining cognitive vitality.
Key to his stability is LEQEMBI, a recently approved medication that has slowed the progression of his condition. Carmona notes that the treatment has played a pivotal role in preventing the advance of Alzheimer’s, enabling him to lead a fuller life than many who suffer from the disease, including his late mother.
As Ralph C. Carmona paves his way through this challenging journey, he remains ambitious, with plans to participate in both the Chicago and New York City marathons later this year. With every mile, he continues to inspire others, showing that a determined spirit and a commitment to health can defy the constraints of age and illness. His story serves as a reminder that it is never too late to reclaim one’s health and passion, turning obstacles into stepping stones.
