Brian Setzer, the acclaimed guitarist of the Stray Cats, has shared a somber update on his health journey. In a heartfelt note to his fans on Friday, Feb. 14, Setzer revealed that he has been diagnosed with an autoimmune disease that has left him unable to play the guitar. The 65-year-old musician expressed his struggles with the condition, stating that he noticed his hands cramping up towards the end of the band’s summer 2024 tour.
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Describing the impact of the autoimmune disease on his ability to play, Setzer compared it to feeling like “wearing a pair of gloves” when trying to strum the guitar, although he clarified that he does not experience any pain. Despite the challenges he faces, Setzer shared some positive developments, mentioning that he has seen progress in being able to perform simple tasks like holding a pen and tying his shoes. Expressing optimism, Setzer affirmed his determination to overcome the disease, stating, “I know I will beat this, it will just take some time.”
Acknowledging the support he has received from his fans and the music community, Setzer expressed gratitude for the Mayo Clinic, where he is receiving treatment. He also received encouraging messages from fellow musicians such as Steve Vai and Chris Cheney, who extended their love and well wishes for his recovery. Vai commended Setzer’s strength, emphasizing the importance of allowing time for a full recovery, while Cheney offered prayers and support, highlighting Setzer’s resilience and talent.

While Setzer did not disclose the specific autoimmune disease he has been diagnosed with, the Cleveland Clinic defines autoimmune diseases as conditions where the immune system mistakenly attacks the body instead of protecting it. There are over 100 different autoimmune diseases categorized into seven main groups based on the affected body systems, including joints, muscles, skin, blood vessels, digestive system, endocrine system, and nervous system. Setzer’s journey reflects the challenges faced by many individuals battling autoimmune conditions and underscores the importance of resilience and support in such circumstances.
The news of Setzer’s health struggles has elicited a wave of support and empathy from fans and followers, emphasizing the impact of his music and presence in the music industry. As a Grammy-winning musician known for his orchestra’s rendition of “Jump Jive an’ Wail,” Setzer’s determination to confront his health challenges resonates with many who admire his talent and spirit. His openness about his health journey serves as a reminder of the resilience required to navigate unexpected hurdles and the power of community in times of difficulty.

Despite the setbacks he is facing, Setzer’s unwavering resolve and positivity shine through his words, reflecting a mindset focused on overcoming obstacles and returning to what he loves – playing music. As he embarks on his journey towards healing and recovery, Setzer’s message of hope and determination resonates with fans and well-wishers around the world. The music community stands in solidarity with Setzer, offering support and encouragement as he navigates this challenging chapter in his life.
In the face of adversity, Brian Setzer’s resilience and determination serve as an inspiration to all those facing their own battles. His candid disclosure about his health struggles not only sheds light on the realities of autoimmune diseases but also underscores the strength of the human spirit in times of adversity. As Setzer continues his journey towards healing, the outpouring of support and well wishes from fans and fellow musicians serves as a testament to the impact of his music and the enduring spirit of the music community.
