The popular dramedy ‘Best Medicine,’ which has quickly garnered a following, made its much-anticipated return to Fox with a special premiere episode on Sunday, 20th September. This marks the beginning of the show’s second season, which promises to delve deeper into the tumultuous life of its protagonist, Dr. Martin Best, played by Josh Charles. Following the premiere, regular episodes will air on Tuesdays at 8 p.m. ET, starting from 22nd September.
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The storyline of the season picks up five months after Dr. Best confessed to his hemophobia and faced scrutiny for permitting his unlicensed assistant, Elaine Denton, portrayed by Cree Cicchino, to draw blood from patients. This season will explore the challenges Dr. Best encounters as he manoeuvres through a probationary period imposed by the health board. “The health board is breathing down his neck,” Charles remarked in a recent interview with Decider. The character’s frustrations are further heightened as the board has begun sending monitors to oversee his work, a point that Charles described as “frustrating,” especially since Dr. Best believes he could perform those tasks with his eyes closed.
In addition to the narrative tension surrounding his professional life, Season 2 promises to explore Dr. Best’s romantic entanglements, notably his rekindled relationship with his former flame, Dr. Eden Montgomery, played by Eliza Coupe. Viewers are also left wondering about the fate of Louisa Gavin, portrayed by Abigail Spencer, and whether she will accept an offer from Sheriff Mark to assist her in becoming a mother. The season opener hints at a whimsical twist, as Sheriff Mark, played by Josh Segarra, expresses a fascination with the fantasy of meeting a mermaid.
Excitement has further escalated as Fox announced that the second season will consist of 14 episodes, an increase from the 13 episodes in the show’s debut. Originally scheduled for 12 episodes after its renewal in March 2026, the order was extended, showcasing the network’s confidence in the show’s potential to develop into a long-running series. Michael Thorn, President of the Fox Television Network, stated that ‘Best Medicine’s successful inaugural season was pivotal in deciding to prioritise its return.
The release schedule outlines initial episodes with clarity; following the premiere, episodes titled “Be Careful What You Fish For,” “Breakin’ In is Hard to Do,” and “Crate Expectations” will air on 22nd September, 29th September, and 6th October, respectively. Although the overall schedule has not been published, it is expected that new episodes will continue to air weekly on Tuesdays.
Fans can look forward to enjoying the latest episodes of ‘Best Medicine’ on Fox, with the added convenience of streaming available via Hulu the day after broadcast, bringing the series even closer to its audience. The first season is also accessible on the streaming platform, offering newcomers a chance to catch up with the show’s early adventures before diving into the second season.
As the new season unfolds, audiences are hopeful for a gripping blend of humour and heartfelt narratives, as Dr. Best confronts personal and professional challenges, weaving through the complexities of his relationships and the pressures of his medical career. With its imaginative storylines, relatable characters, and engaging performances, ‘Best Medicine’ continues to captivate viewers, establishing itself as a standout addition to Fox’s primetime lineup.